Asthma-susceptibility variants identified using probands in case-control and family-based analyses.

ABSTRACT:

Background

Asthma is a chronic respiratory disease whose genetic basis has been explored for over two decades, most recently via genome-wide association studies. We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs.

Methods

We used probands from the Childhood Asthma Management Program (CAMP) in two primary genome-wide association study designs: (1) probands were combined with publicly available population controls in a case-control design, and (2) probands and their parents were used in a family-based design. We followed a two-stage replication process utilizing three independent populations to validate our primary findings.

Results

We found that single nucleotide polymorp

SUBMITTER: Himes BE 

PROVIDER: S-EPMC2927535 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature