CCL25-CCR9 interaction modulates ovarian cancer cell migration, metalloproteinase expression, and invasion.

ABSTRACT:

Background

Ovarian carcinoma (OvCa) is the most lethal gynecological malignancy among women and its poor prognosis is mainly due to metastasis. Chemokine receptor CCR9 is primarily expressed by a small subset of immune cells and its only natural ligand, CCL25, is largely expressed in the thymus, which involutes with age. Other than the thymus, CCL25 is expressed by the small bowel. Interactions between CCL25 and CCR9 have been implicated in leukocyte trafficking to the small bowel, a frequent metastatic site for OvCa cells. The current study shows OvCa tissue and cells significantly express CCR9, which interacts with CCL25 to support carcinoma cell migration and invasion.

Methods

RT-PCR and flow cytometry techniques were used to quantify the expression CCR9 by OvCa cells. Ov

SUBMITTER: Johnson EL 

PROVIDER: S-EPMC2927595 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature