Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis.

ABSTRACT:

Objective

It is increasingly being appreciated that multiple autoimmune diseases share common susceptibility genes. The tumour necrosis factor ligand superfamily member 4 gene (TNFSF4, OX40L), which encodes for the T cell costimulatory molecule OX40 ligand, has been identified as a susceptibility gene for the development of systemic lupus erythematosus (SLE). Accordingly, the aim of the current study was to investigate the possible association of the TNFSF4 gene region with systemic sclerosis (SSc), an autoimmune disease that leads to the development of cutaneous and visceral fibrosis.

Methods

A total of 9 single nucleotide polymorphisms (SNPs) in the TNFSF4 gene region, previously associated with susceptibility to SLE, were tested for association with SSc in a collection of

SUBMITTER: Gourh P 

PROVIDER: S-EPMC2927683 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature