Estimating the parameters of selection on nonsynonymous mutations in Drosophila pseudoobscura and D. miranda.

ABSTRACT: We present the results of surveys of diversity in sets of >40 X-linked and autosomal loci in samples from natural populations of Drosophila miranda and D. pseudoobscura, together with their sequence divergence from D. affinis. Mean silent site diversity in D. miranda is approximately one-quarter of that in D. pseudoobscura; mean X-linked silent diversity is about three-quarters of that for the autosomes in both species. Estimates of the distribution of selection coefficients against heterozygous, deleterious nonsynonymous mutations from two different methods suggest a wide distribution, with coefficients of variation greater than one, and with the average segregating amino acid mutation being subject to only very weak selection. Only a small fraction of new amino acid mutations behave as e

SUBMITTER: Haddrill PR 

PROVIDER: S-EPMC2927764 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature