Leukocyte subset-derived genomewide expression profiles in pediatric septic shock.

ABSTRACT:

Objective

To directly assess whether genomewide expression profiles derived from leukocyte subsets are comparable to that of whole blood as measured by enrichment for genes corresponding to metabolic and signaling pathways.

Design

Prospective observational study involving microarray-based bioinformatics based on RNA individually derived from whole blood, neutrophils, monocytes, and lymphocytes, respectively.

Setting

Three pediatric intensive care units in the United States.

Patients

Children < or =10 yrs of age: five normal control subjects and 13 meeting criteria for septic shock on day 1 of presentation to the pediatric intensive care unit.

Interventions

None other than standard care.

Measurements and main results

Baseline analyses using whole b

SUBMITTER: Wong HR 

PROVIDER: S-EPMC2927840 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature