Perinatal folate-related exposures and risk of psychotic symptoms in the ALSPAC birth cohort.

ABSTRACT:

Background

It is unclear to what extent non-clinical psychotic experiences during childhood and adolescence share underlying aetiological mechanisms with schizophrenia. One candidate mechanism for schizophrenia involves the epigenetic status of the developing fetus, which depends on the internal folate-status of mother and child. Our study examines the relationships between multiple determinants of perinatal folate-status and development of psychotic experiences in adolescence.

Methods

Study participants were up to 5344 mother-child pairs from the Avon Longitudinal Study of Parents and their Children, UK, with information on maternal and/or child MTHFR C677T genotype, maternal folate intake (supplementation at 18/32- weeks gestation; dietary intake at 32- weeks gestation) an

SUBMITTER: Glaser B 

PROVIDER: S-EPMC2927900 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature