A phylogenetic survey of myotubularin genes of eukaryotes: distribution, protein structure, evolution, and gene expression.

ABSTRACT:

Background

Phosphorylated phosphatidylinositol (PtdIns) lipids, produced and modified by PtdIns kinases and phosphatases, are critical to the regulation of diverse cellular functions. The myotubularin PtdIns-phosphate phosphatases have been well characterized in yeast and especially animals, where multiple isoforms, both catalytically active and inactive, occur. Myotubularin mutations bring about disruption of cellular membrane trafficking, and in humans, disease. Previous studies have suggested that myotubularins are widely distributed amongst eukaryotes, but key evolutionary questions concerning the origin of different myotubularin isoforms remain unanswered, and little is known about the function of these proteins in most organisms.

Results

We have identified 80 myotubula

SUBMITTER: Kerk D 

PROVIDER: S-EPMC2927912 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature