Characterization of the apoptotic response of human leukemia cells to organosulfur compounds.

ABSTRACT:

Background

Novel therapeutic agents that selectively induce tumor cell death are urgently needed in the clinical management of cancers. Such agents would constitute effective adjuvant approaches to traditional chemotherapy regimens. Organosulfur compounds (OSCs), such as diallyl disulfide, have demonstrated anti-proliferative effects on cancer cells. We have previously shown that synthesized relatives of dysoxysulfone, a natural OSC derived from the Fijian medicinal plant, Dysoxylum richi, possess tumor-specific antiproliferative effects and are thus promising lead candidates.

Methods

Because our structure-activity analyses showed that regions flanking the disulfide bond mediated specificity, we synthesized 18 novel OSCs by structural modification of the most promising dysox

SUBMITTER: Wong WW 

PROVIDER: S-EPMC2928001 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature