Association of maternally inherited GNAS alleles with African-American male birth weight.

ABSTRACT:

Objective

Human birth weight variation has a significant genetic component and important clinical consequences. We performed a survey of single nucleotide polymorphisms (SNPs) in 14 candidate genes to identify associations with birth weight variation.

Methods

SNP variation was surveyed in 221 healthy African-American mother-newborn pairs. Genes were selected based on previous association with obesity-related traits, significant differences in circulating protein levels in low birth weight pregnancies or association with newborn size in model organisms or growth disorders in humans. Association was tested via multiple linear regression with adjustment for significant covariables.

Results

Under a dominant model SNP rs7754561 of ENPPI was significantly associated with bi

SUBMITTER: Adkins RM 

PROVIDER: S-EPMC2928065 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature