Dynamics of dendritic cell maturation are identified through a novel filtering strategy applied to biological time-course microarray replicates.

ABSTRACT:

Background

Dendritic cells (DC) play a central role in primary immune responses and become potent stimulators of the adaptive immune response after undergoing the critical process of maturation. Understanding the dynamics of DC maturation would provide key insights into this important process. Time course microarray experiments can provide unique insights into DC maturation dynamics. Replicate experiments are necessary to address the issues of experimental and biological variability. Statistical methods and averaging are often used to identify significant signals. Here a novel strategy for filtering of replicate time course microarray data, which identifies consistent signals between the replicates, is presented and applied to a DC time course microarray experiment.

Results

SUBMITTER: Olex AL 

PROVIDER: S-EPMC2928180 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature