Modeling core metabolism in cancer cells: surveying the topology underlying the Warburg effect.

ABSTRACT:

Background

Alterations on glucose consumption and biosynthetic activity of amino acids, lipids and nucleotides are metabolic changes for sustaining cell proliferation in cancer cells. Irrevocable evidence of this fact is the Warburg effect which establishes that cancer cells prefers glycolysis over oxidative phosphorylation to generate ATP. Regulatory action over metabolic enzymes has opened a new window for designing more effective anti-cancer treatments. This enterprise is not trivial and the development of computational models that contribute to identifying potential enzymes for breaking the robustness of cancer cells is a priority.

Methodology/principal findings

This work presents a constraint-base modeling of the most experimentally studied metabolic pathways supporting

SUBMITTER: Resendis-Antonio O 

PROVIDER: S-EPMC2928278 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature