The presence of GAD and IA-2 antibodies in youth with a type 2 diabetes phenotype: results from the TODAY study.

ABSTRACT:

Objective

To determine the frequency of islet cell autoimmunity in youth clinically diagnosed with type 2 diabetes and describe associated clinical and laboratory findings.

Research design and methods

Children (10-17 years) diagnosed with type 2 diabetes were screened for participation in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study. Measurements included GAD-65 and insulinoma-associated protein 2 autoantibodies using the new National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health (NIDDK/NIH) standardized assays, a physical examination, and fasting lipid, C-peptide, and A1C determinations.

Results

Of the 1,206 subjects screened and considered clinically to have type 2 diabetes, 118 (9.8%) were

SUBMITTER: Klingensmith GJ 

PROVIDER: S-EPMC2928346 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature