Doses of insulin and its analogues and cancer occurrence in insulin-treated type 2 diabetic patients.

ABSTRACT:

Objective

Recent epidemiological studies suggested that some insulin analogues could be associated with increased risk of cancer. The present study is aimed at assessing the long-term association of different insulin analogues with cancer incidence.

Research design and methods

A nested case-control study dataset was generated from the cohort study dataset (n = 1,340 insulin-treated diabetic outpatients) by sampling control subjects from the risk sets. For each case subject, the control subjects (up to five) were chosen randomly from those members of the cohort who are at risk for the same follow-up time of the case subject. Five-year age classes, sex, and BMI classes (<18.5, 18.5-24.9, 25-29.9, and >or=30 kg/m(2)) were considered as additional categorical matching variables.

SUBMITTER: Mannucci E 

PROVIDER: S-EPMC2928350 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature