Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder.

ABSTRACT:

Objective

To summarize and evaluate the state of knowledge regarding the role of measured gene-by-environment interactions in relation to attention-deficit/hyperactivity disorder.

Method

A selective review of methodologic issues was followed by a systematic search for relevant articles on measured gene-by-environment interactions; the search yielded 16 studies, which are discussed in qualitative fashion.

Results

Relatively consistent evidence points to the interaction of genotype with psychosocial factors in the development of attention-deficit/hyperactivity disorder. The next step is to identify the mechanisms on the environment side and the gene combinations on the genetic side accounting for this effect. In contrast, evidence for gene-by-environment interactions in

SUBMITTER: Nigg J 

PROVIDER: S-EPMC2928573 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature