Case-control genome-wide association study of attention-deficit/hyperactivity disorder.

ABSTRACT:

Objective

Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. Thus additional genomewide association studies (GWAS) are needed.

Method

We used case-control analyses of 896 cases with DSM-IV ADHD genotyped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. Data were analyzed using a generalized linear model.

Results

No genome-wide significant associations were found. The most significant results implicated the follo

SUBMITTER: Neale BM 

PROVIDER: S-EPMC2928577 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature