Comparative genomics of Gardnerella vaginalis strains reveals substantial differences in metabolic and virulence potential.

ABSTRACT:

Background

Gardnerella vaginalis is described as a common vaginal bacterial species whose presence correlates strongly with bacterial vaginosis (BV). Here we report the genome sequencing and comparative analyses of three strains of G. vaginalis. Strains 317 (ATCC 14019) and 594 (ATCC 14018) were isolated from the vaginal tracts of women with symptomatic BV, while Strain 409-05 was isolated from a healthy, asymptomatic individual with a Nugent score of 9.

Principal findings

Substantial genomic rearrangement and heterogeneity were observed that appeared to have resulted from both mobile elements and substantial lateral gene transfer. These genomic differences translated to differences in metabolic potential. All strains are equipped with significant virulence potential, includ

SUBMITTER: Yeoman CJ 

PROVIDER: S-EPMC2928729 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature