Gene expression variability within and between human populations and implications toward disease susceptibility.

ABSTRACT: Variations in gene expression level might lead to phenotypic diversity across individuals or populations. Although many human genes are found to have differential mRNA levels between populations, the extent of gene expression that could vary within and between populations largely remains elusive. To investigate the dynamic range of gene expression, we analyzed the expression variability of ∼18, 000 human genes across individuals within HapMap populations. Although ∼20% of human genes show differentiated mRNA levels between populations, our results show that expression variability of most human genes in one population is not significantly deviant from another population, except for a small fraction that do show substantially higher expression variability in a particular population. By assoc

SUBMITTER: Li J 

PROVIDER: S-EPMC2928754 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature