Consistent association of type 2 diabetes risk variants found in europeans in diverse racial and ethnic groups.

ABSTRACT: It has been recently hypothesized that many of the signals detected in genome-wide association studies (GWAS) to T2D and other diseases, despite being observed to common variants, might in fact result from causal mutations that are rare. One prediction of this hypothesis is that the allelic associations should be population-specific, as the causal mutations arose after the migrations that established different populations around the world. We selected 19 common variants found to be reproducibly associated to T2D risk in European populations and studied them in a large multiethnic case-control study (6,142 cases and 7,403 controls) among men and women from 5 racial/ethnic groups (European Americans, African Americans, Latinos, Japanese Americans, and Native Hawaiians). In analysis pooled ac

SUBMITTER: Waters KM 

PROVIDER: S-EPMC2928808 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature