The role of the polycystic ovary syndrome susceptibility locus D19S884 allele 8 in maternal glycemia and fetal size.

ABSTRACT:

Context

The high incidence of insulin resistance, type 2 diabetes, and metabolic syndrome in Western societies and their impact on quality of life emphasize the importance of identifying underlying susceptibility loci for metabolic diseases. The polycystic ovary syndrome (PCOS) susceptibility locus D19S884 allele 8 (A8) is associated with measures of insulin resistance, beta-cell dysfunction, and other metabolic phenotypes in PCOS families. We now investigate the role of D19S884 A8 in pregnancy.

Objective

Using the multiethnic Hyperglycemia and Adverse Pregnancy Outcome cohort, we assessed the associations of D19S884 A8 with measures of maternal glycemia and fetal size.

Design

We tested for association of maternal D19S884 A8 with maternal outcomes (fasting, 1-h, and 2

SUBMITTER: Ackerman CM 

PROVIDER: S-EPMC2928903 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature