Heritable individual-specific and allele-specific chromatin signatures in humans.

ABSTRACT: The extent to which variation in chromatin structure and transcription factor binding may influence gene expression, and thus underlie or contribute to variation in phenotype, is unknown. To address this question, we cataloged both individual-to-individual variation and differences between homologous chromosomes within the same individual (allele-specific variation) in chromatin structure and transcription factor binding in lymphoblastoid cells derived from individuals of geographically diverse ancestry. Ten percent of active chromatin sites were individual-specific; a similar proportion were allele-specific. Both individual-specific and allele-specific sites were commonly transmitted from parent to child, which suggests that they are heritable features of the human genome. Our study shows

SUBMITTER: McDaniell R 

PROVIDER: S-EPMC2929018 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature