Epithelial to mesenchymal transition is mechanistically linked with stem cell signatures in prostate cancer cells.

ABSTRACT:

Background

Current management of patients diagnosed with prostate cancer (PCa) is very effective; however, tumor recurrence with Castrate Resistant Prostate Cancer (CRPC) and subsequent metastasis lead to poor survival outcome, suggesting that there is a dire need for novel mechanistic understanding of tumor recurrence, which would be critical for designing novel therapies. The recurrence and the metastasis of PCa are tightly linked with the biology of prostate cancer stem cells or cancer-initiating cells that is reminiscent of the acquisition of Epithelial to Mesenchymal Transition (EMT) phenotype. Increasing evidence suggests that EMT-type cells share many biological characteristics with cancer stem-like cells.

Methodology/principal findings

In this study, we found that PC

SUBMITTER: Kong D 

PROVIDER: S-EPMC2929211 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature