Evaluation of high-resolution microarray platforms for genomic profiling of bone tumours.

ABSTRACT:

Background

Several high-density oligonucleotide microarray platforms are available for genome-wide single nucleotide polymorphism (SNP) detection and microarray-based comparative genomic hybridisation (array CGH), which may be used to detect copy number aberrations in human tumours. As part of the EuroBoNeT network of excellence for research on bone tumours (eurobonet.eu), we have evaluated four different commercial high-resolution microarray platforms in order to identify the most appropriate technology for mapping DNA copy number aberrations in such tumours.

Findings

DNA from two different cytogenetically well-characterized bone sarcoma cell lines, representing a simple and a complex karyotype, respectively, was tested in duplicate on four high-resolution microarray platfo

SUBMITTER: Kresse SH 

PROVIDER: S-EPMC2929238 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature