Identifying loci for the overlap between attention-deficit/hyperactivity disorder and autism spectrum disorder using a genome-wide QTL linkage approach.

ABSTRACT:

Objective

The genetic basis for autism spectrum disorder (ASD) symptoms in children with attention-deficit/hyperactivity disorder (ADHD) was addressed using a genome-wide linkage approach.

Method

Participants of the International Multi-Center ADHD Genetics study comprising 1,143 probands with ADHD and 1,453 siblings were analyzed. The total and subscale scores of the Social Communication Questionnaire (SCQ) were used as quantitative traits for multipoint regression-based linkage analyses on 5,407 autosomal single-nucleotide polymorphisms applying MERLIN-regress software, both without and with inclusion of ADHD symptom scores as covariates.

Results

The analyses without ADHD symptom scores as covariates resulted in three suggestive linkage signals, i.e., on chromosomes

SUBMITTER: Nijmeijer JS 

PROVIDER: S-EPMC2929476 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature