Overexpression of translocator protein in inflammatory bowel disease: potential diagnostic and treatment value.

ABSTRACT:

Background

Inflammatory bowel diseases (IBDs), such as ulcerative colitis and Crohn's disease, are chronic inflammatory disorders that increase the risk for colorectal cancer. The mitochondrial translocator protein (TSPO) is a high-affinity drug- and cholesterol-binding protein expressed in the colon and its expression is increased in colon cancers. The aim of this study was to investigate TSPO expression in IBD biopsies and to establish an animal model of IBD to examine the role of TSPO. In addition, we evaluated the potential use of TSPO drug ligands in diagnosing and treating IBD.

Methods

TSPO expression in IBD biopsies was evaluated using immunohistochemistry. IBD was induced in a rat experimental model via treatment with dextran sodium sulfate (DSS). Colon morphology, T

SUBMITTER: Ostuni MA 

PROVIDER: S-EPMC2930116 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature