Early severe inflammatory responses to uropathogenic E. coli predispose to chronic and recurrent urinary tract infection.

ABSTRACT: Chronic infections are an increasing problem due to the aging population and the increase in antibiotic resistant organisms. Therefore, understanding the host-pathogen interactions that result in chronic infection is of great importance. Here, we investigate the molecular basis of chronic bacterial cystitis. We establish that introduction of uropathogenic E. coli (UPEC) into the bladders of C3H mice results in two distinct disease outcomes: resolution of acute infection or development of chronic cystitis lasting months. The incidence of chronic cystitis is both host strain and infectious dose-dependent. Further, development of chronic cystitis is preceded by biomarkers of local and systemic acute inflammation at 24 hours post-infection, including severe pyuria and bladder inflammation with

SUBMITTER: Hannan TJ 

PROVIDER: S-EPMC2930321 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature