Stress coping stimulates hippocampal neurogenesis in adult monkeys.

ABSTRACT: Coping with intermittent social stress is an essential aspect of living in complex social environments. Coping tends to counteract the deleterious effects of stress and is thought to induce neuroadaptations in corticolimbic brain systems. Here we test this hypothesis in adult squirrel monkey males exposed to intermittent social separations and new pair formations. These manipulations simulate conditions that typically occur in male social associations because of competition for limited access to residency in mixed-sex groups. As evidence of coping, we previously confirmed that cortisol levels initially increase and then are restored to prestress levels within several days of each separation and new pair formation. Follow-up studies with exogenous cortisol further established that feedback

SUBMITTER: Lyons DM 

PROVIDER: S-EPMC2930418 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature