Mechanisms of suspended animation are revealed by transcript profiling of diapause in the flesh fly.

ABSTRACT: Diapause is a widespread adaptation to seasonality across invertebrate taxa. It is critical for persistence in seasonal environments, synchronizing life histories with favorable, resource-rich conditions and mitigating exposure to harsh environments. Despite some promising recent progress, however, we still know very little about the molecular modifications underlying diapause. We used transcriptional profiling to identify key groups of genes and pathways differentially regulated during pupal diapause, dynamically regulated across diapause development, and differentially regulated after diapause was pharmacologically terminated in the flesh fly Sarcophaga crassipalpis. We describe major shifts in stress axes, endocrine signaling, and metabolism that accompany diapause, several of which app

SUBMITTER: Ragland GJ 

PROVIDER: S-EPMC2930464 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature