Dynamic antibody responses to the Mycobacterium tuberculosis proteome.

ABSTRACT: Considerable effort has been directed toward controlling tuberculosis, which kills almost two million people yearly. High on the research agenda is the discovery of biomarkers of active tuberculosis (TB) for diagnosis and for monitoring treatment outcome. Rational biomarker discovery requires understanding host-pathogen interactions leading to biomarker expression. Here we report a systems immunology approach integrating clinical data and bacterial metabolic and regulatory information with high-throughput detection in human serum of antibodies to the entire Mycobacterium tuberculosis proteome. Sera from worldwide TB suspects recognized approximately 10% of the bacterial proteome. This result defines the M. tuberculosis immunoproteome, which is rich in membrane-associated and extracellular

SUBMITTER: Kunnath-Velayudhan S 

PROVIDER: S-EPMC2930474 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature