Transcriptional reprogramming in nonhuman primate (rhesus macaque) tuberculosis granulomas.

ABSTRACT:

Background

In response to Mtb infection, the host remodels the infection foci into a dense mass of cells known as the granuloma. The key objective of the granuloma is to contain the spread of Mtb into uninfected regions of the lung. However, it appears that Mtb has evolved mechanisms to resist killing in the granuloma. Profiling granuloma transcriptome will identify key immune signaling pathways active during TB infection. Such studies are not possible in human granulomas, due to various confounding factors. Nonhuman Primates (NHPs) infected with Mtb accurately reflect human TB in clinical and pathological contexts.

Methodology/principal findings

We studied transcriptomics of granuloma lesions in the lungs of NHPs exhibiting active TB, during early and late stages of infecti

SUBMITTER: Mehra S 

PROVIDER: S-EPMC2930844 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature