Identification of cis-regulatory elements in the mammalian genome: the cREMaG database.

ABSTRACT:

Background

A growing number of gene expression-profiling datasets provides a reliable source of information about gene co-expression. In silico analyses of the properties shared among the promoters of co-expressed genes facilitates the identification of transcription factors (TFs) involved in the co-regulation of those genes. Our previous experience with microarray data led to the development of a database suitable for the examination of regulatory motifs in the promoters of co-expressed genes.

Methodology

We introduce the cREMaG (cis-Regulatory Elements in the Mammalian Genome) system designed for in silico studies of the promoter properties of co-regulated mammalian genes. The cREMaG system offers an analysis of data obtained from human, mouse, rat, bovine and canine gene

SUBMITTER: Piechota M 

PROVIDER: S-EPMC2930848 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature