Rapid catalyst screening by a continuous-flow microreactor interfaced with ultra-high-pressure liquid chromatography.

ABSTRACT: A high-throughput screening system for homogeneous catalyst discovery has been developed by integrating a continuous-flow capillary-based microreactor with ultra-high-pressure liquid chromatography (UHPLC) for fast online analysis. Reactions are conducted in distinct and stable zones in a flow stream that allows for time and temperature regulation. UHPLC detection at high temperature allows high throughput online determination of substrate, product, and byproduct concentrations. We evaluated the efficacies of a series of soluble acid catalysts for an intramolecular Friedel-Crafts addition into an acyliminium ion intermediate within 1 day and with minimal material investment. The effects of catalyst loading, reaction time, and reaction temperature were also screened. This system exhibited h

SUBMITTER: Fang H 

PROVIDER: S-EPMC2930889 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature