Increased expression of cysteine cathepsins in ovarian tissue from chickens with ovarian cancer.

ABSTRACT:

Background

Cysteine cathepsins (CTSs) are involved in the degradation and remodeling of the extracellular matrix and are associated with cell transformation, differentiation, motility, and adhesion. These functions are also related to cancer cell invasion and metastasis. Chickens spontaneously develop epithelial ovarian cancer and are therefore a good animal model for human ovarian cancer. However, no studies have investigated the expression of CTSs in chickens with ovarian cancer.

Methods

Cancerous (n = 5) and normal (n = 3) ovaries were collected from 2-to 3-year-old hens, and ovarian tissue samples were collected for study. Ovarian cancers were evaluated with hematoxylin and eosin staining. Reverse transcriptase and quantitative PCR analyses, in situ hybridization analysi

SUBMITTER: Ahn SE 

PROVIDER: S-EPMC2931516 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature