Increased expression of bcl11b leads to chemoresistance accompanied by G1 accumulation.

ABSTRACT:

Background

The expression of BCL11B was reported in T-cells, neurons and keratinocytes. Aberrations of BCL11B locus leading to abnormal gene transcription were identified in human hematological disorders and corresponding animal models. Recently, the elevated levels of Bcl11b protein have been described in a subset of squameous cell carcinoma cases. Despite the rapidly accumulating knowledge concerning Bcl11b biology, the contribution of this protein to normal or transformed cell homeostasis remains open.

Methodology/principal findings

Here, by employing an overexpression strategy we revealed formerly unidentified features of Bcl11b. Two different T-cell lines were forced to express BCL11B at levels similar to those observed in primary T-cell leukemias. This resulted in mark

SUBMITTER: Grabarczyk P 

PROVIDER: S-EPMC2932720 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature