The IP3 receptor regulates cardiac hypertrophy in response to select stimuli.

ABSTRACT:

Rationale

Inositol 1,4,5-trisphosphate (IP(3)) is a second messenger that regulates intracellular Ca(2+) release through IP(3) receptors located in the sarco(endo)plasmic reticulum of cardiac myocytes. Many prohypertrophic G protein-coupled receptor (GPCR) signaling events lead to IP(3) liberation, although its importance in transducing the hypertrophic response has not been established in vivo.

Objective

Here, we generated conditional, heart-specific transgenic mice with both gain- and loss-of-function for IP(3) receptor signaling to examine its hypertrophic growth effects following pathological and physiological stimulation.

Methods and results

Overexpression of the mouse type-2 IP(3) receptor (IP(3)R2) in the heart generated mild baseline cardiac hypertrophy at 3 m

SUBMITTER: Nakayama H 

PROVIDER: S-EPMC2933281 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature