Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus.

ABSTRACT:

Background

The influenza A virus is an important infectious cause of morbidity and mortality in humans and was responsible for 3 pandemics in the 20th century. As the replication of the influenza virus is based on its host's machinery, codon usage of its viral genes might be subject to host selection pressures, especially after interspecies transmission. A better understanding of viral evolution and host adaptive responses might help control this disease.

Results

Relative Synonymous Codon Usage (RSCU) values of the genes from segment 1 to segment 6 of avian and human influenza viruses, including pandemic H1N1, were studied via Correspondence Analysis (CA). The codon usage patterns of seasonal human influenza viruses were distinct among their subtypes and different from those

SUBMITTER: Wong EH 

PROVIDER: S-EPMC2933640 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature