Transcriptomic biomarkers of the response of hospitalized geriatric patients with infectious diseases.

ABSTRACT:

Background

Infectious diseases are significant causes of morbidity and mortality among elderly populations. However, the relationship between oxidative stress, immune function and inflammatory response in acute phase of the infectious disease is poorly understood.

Results

Herein the abundance of a selection of 148 transcripts involved in immunosenescence and stress response was compared in total RNA of PBMC of 28 healthy aged probands and 39 aged patients in acute phase of infectious disease (day 2-4 after hospitalization) or in convalescence phase (day 7-10). This study provides a list of 24 differentially abundant transcript species in the acute phase versus healthy aged. For instance, transcripts associated with inflammatory and anti-inflammatory reactions (TNFRSF1A, IL1R

SUBMITTER: Vo TK 

PROVIDER: S-EPMC2933667 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature