Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis.

ABSTRACT: Estrogen signaling is required for the proliferation of normal breast epithelial cells. However, prophylactic inhibition of estrogen signaling fails to prevent 56% of human breast cancer cases. The underlying mechanism is not well understood. Aberrant activation of growth factor signaling is known to provide alternative proliferation pathways in breast cells that are fully transformed, but it is not known whether activation of growth factor signaling can substitute for estrogen signaling in causing aberrant proliferation in the normal breast epithelium. Here, we report that in a retrovirus-based somatic mouse model (replication-competent ALV-LTR splice acceptor/tumor virus A) that closely mimics the evolution of sporadic human breast cancers, mammary epithelial cells harboring PyMT or acti

SUBMITTER: Toneff MJ 

PROVIDER: S-EPMC2933692 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature