Chaperone expression profiles correlate with distinct physiological states of Plasmodium falciparum in malaria patients.

ABSTRACT:

Background

Molecular chaperones have been shown to be important in the growth of the malaria parasite Plasmodium falciparum and inhibition of chaperone function by pharmacological agents has been shown to abrogate parasite growth. A recent study has demonstrated that clinical isolates of the parasite have distinct physiological states, one of which resembles environmental stress response showing up-regulation of specific molecular chaperones.

Methods

Chaperone networks operational in the distinct physiological clusters in clinical malaria parasites were constructed using cytoscape by utilizing their clinical expression profiles.

Results

Molecular chaperones show distinct profiles in the previously defined physiologically distinct states. Further, expression profiles o

SUBMITTER: Pallavi R 

PROVIDER: S-EPMC2933700 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature