The h current is a candidate mechanism for regulating the sliding modification threshold in a BCM-like synaptic learning rule.

ABSTRACT: Hebbian synaptic plasticity acts as a positive feedback mechanism and can destabilize a neuronal network unless concomitant homeostatic processes that counterbalance this instability are activated. Within a Bienenstock-Cooper-Munro (BCM)-like plasticity framework, such compensation is achieved through a modification threshold that slides in an activity-dependent fashion. Although the BCM-like plasticity framework has been a useful formulation to understand synaptic plasticity and metaplasticity, a mechanism for the activity-dependent regulation of this modification threshold has remained an open question. In this simulation study based on CA1 pyramidal cells, we use a modification of the calcium-dependent hypothesis proposed elsewhere and show that a change in the hyperpolarization-activat

SUBMITTER: Narayanan R 

PROVIDER: S-EPMC2934916 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature