The roles of somatostatin-expressing (GIN) and fast-spiking inhibitory interneurons in UP-DOWN states of mouse neocortex.

ABSTRACT: The neocortex contains multiple types of inhibitory neurons whose properties suggest they may play different roles within the cortical circuit. By recording from three cell types during two distinct network states (UP and DOWN states) in vitro, we were able to quantify differences in firing characteristics between these cells during different network regimes. We recorded from regular-spiking (RS) excitatory cells and two types of inhibitory neurons, the fast-spiking (FS) neurons and GFP- (and somatostatin-) expressing inhibitory neurons (GIN), in layer 2/3 of slices from mouse somatosensory neocortex. Comparisons of firing characteristics between these cells during UP- and DOWN-states showed several patterns. First, of these cell types, only GIN cells fired persistently during DOWN-states,

SUBMITTER: Fanselow EE 

PROVIDER: S-EPMC2934925 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature