Display of recombinant proteins on Bacillus subtilis spores, using a coat-associated enzyme as the carrier.

ABSTRACT: The display of proteins such as feed enzymes at the surface of bacterial spore systems has a great potential use for animal feed. Feed enzymes increase the digestibility of nutrients, leading to greater efficiency in the manufacturing of animal products and minimizing the environmental impact of increased animal production. To deliver their full potential in the gut, feed enzymes must survive the harsh conditions of the feed preparation and the gastrointestinal tract. The well-documented resistance of spores to harsh environments, together with the ability to use proteins that compose the spore as carriers for the display of passenger proteins, suggests that spores could be used as innovative tools to improve the formulation of bioactive molecules. Although some successful examples have be

SUBMITTER: Potot S 

PROVIDER: S-EPMC2935070 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature