Adaptations to new environments in humans: the role of subtle allele frequency shifts.

ABSTRACT: Humans show tremendous phenotypic diversity across geographically distributed populations, and much of this diversity undoubtedly results from genetic adaptations to different environmental pressures. The availability of genome-wide genetic variation data from densely sampled populations offers unprecedented opportunities for identifying the loci responsible for these adaptations and for elucidating the genetic architecture of human adaptive traits. Several approaches have been used to detect signals of selection in human populations, and these approaches differ in the assumptions they make about the underlying mode of selection. We contrast the results of approaches based on haplotype structure and differentiation of allele frequencies to those from a method for identifying single nucleot

SUBMITTER: Hancock AM 

PROVIDER: S-EPMC2935101 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature