Composite MRI scores improve correlation with EDSS in multiple sclerosis.

ABSTRACT:

Background

Quantitative measures derived from magnetic resonance imaging (MRI) have been widely investigated as non-invasive biomarkers in multiple sclerosis (MS). However, the correlation of single measures with Expanded Disability Status Scale (EDSS) is poor, especially for studies with large population samples.

Objective

To explore the correlation of MRI-derived measures with EDSS through composite MRI scores.

Methods

Magnetic resonance images of 126 patients with relapsing-remitting MS were segmented into white and gray matter, cerebrospinal fluid, T2-hyperintense lesions, gadolinium contrast-enhancing lesions, T1-hypointense lesions ('black holes': BH). The volumes and average T2 values for each of these tissues and lesions were calculated and converted to a z-sc

SUBMITTER: Poonawalla AH 

PROVIDER: S-EPMC2935291 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature