Enhanced aortic macrophage lipid accumulation and inflammatory response in LDL receptor null mice fed an atherogenic diet.

ABSTRACT: The effect of an atherogenic diet on inflammatory response and elicited peritoneal macrophage (Mphi) cholesterol accumulation in relation to aortic lesion formation was assessed in LDL receptor null (LDLr-/-) mice. Mice were fed an atherogenic or control diet for 32 weeks. The atherogenic relative to control diet resulted in significantly higher plasma monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor alpha (TNFalpha) and interleukin-6 (IL-6) concentrations, more aortic wall Mphi deposition, higher serum non HDL-cholesterol concentrations and total cholesterol to HDL-cholesterol ratios, and greater accumulation of both aortic free and esterified cholesterol. Elicited peritoneal Mphi selectively accumulated longer chain unsaturated fatty acids in their membrane, independent

SUBMITTER: Wang S 

PROVIDER: S-EPMC2935317 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature