Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells.

ABSTRACT: Numerous responses are triggered by light in the cell. How the light signal is detected and transduced into a cellular response is still an enigma. Each zebrafish cell has the capacity to directly detect light, making this organism particularly suitable for the study of light dependent transcription. To gain insight into the light signalling mechanism we identified genes that are activated by light exposure at an early embryonic stage, when specialised light sensing organs have not yet formed. We screened over 14,900 genes using micro-array GeneChips, and identified 19 light-induced genes that function primarily in light signalling, stress response, and DNA repair. Here we reveal that PAR Response Elements are present in all promoters of the light-induced genes, and demonstrate a pivotal r

SUBMITTER: Gavriouchkina D 

PROVIDER: S-EPMC2935359 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature