Expression profiling of a genetic animal model of depression reveals novel molecular pathways underlying depressive-like behaviours.

ABSTRACT:

Background

The Flinders model is a validated genetic rat model of depression that exhibits a number of behavioural, neurochemical and pharmacological features consistent with those observed in human depression.

Principal findings

In this study we have used genome-wide microarray expression profiling of the hippocampus and prefrontal/frontal cortex of Flinders Depression Sensitive (FSL) and control Flinders Depression Resistant (FRL) lines to understand molecular basis for the differences between the two lines. We profiled two independent cohorts of Flinders animals derived from the same colony six months apart, each cohort statistically powered to allow independent as well as combined analysis. Using this approach, we were able to validate using real-time-PCR a core set of g

SUBMITTER: Blaveri E 

PROVIDER: S-EPMC2935375 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature