Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits.

ABSTRACT:

Background

Neuropeptides are critical integrative elements within the central circadian clock in the suprachiasmatic nucleus (SCN), where they mediate both cell-to-cell synchronization and phase adjustments that cause light entrainment. Forward peptidomics identified little SAAS, derived from the proSAAS prohormone, among novel SCN peptides, but its role in the SCN is poorly understood.

Methodology/principal findings

Little SAAS localization and co-expression with established SCN neuropeptides were evaluated by immunohistochemistry using highly specific antisera and stereological analysis. Functional context was assessed relative to c-FOS induction in light-stimulated animals and on neuronal circadian rhythms in glutamate-stimulated brain slices. We found that little SAAS-ex

SUBMITTER: Atkins N 

PROVIDER: S-EPMC2935382 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature