Computational analysis of tissue-specific gene networks: application to murine retinal functional studies.

ABSTRACT:

Motivation

The vertebrate retina is a complex neuronal tissue, and its development, normal functioning and response to injury and disease is subject to a variety of genetic factors. To understand better the regulatory and functional relationships between the genes expressed within the retina, we constructed an interactive gene network of the mouse retina by applying a Bayesian statistics approach to information derived from a variety of gene expression, protein-protein interaction and gene ontology annotation databases.

Results

The network contains 673 retina-related genes. Most of them are obtained through manual literature-based curation, while the others are the genes preferentially expressed in the retina. These retina-related genes are linked by 3403 potential functiona

SUBMITTER: Hu J 

PROVIDER: S-EPMC2935398 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature