A novel approach for determining environment-specific protein costs: the case of Arabidopsis thaliana.

ABSTRACT:

Motivation

Comprehensive understanding of cellular processes requires development of approaches which consider the energetic balances in the cell. The existing approaches that address this problem are based on defining energy-equivalent costs which do not include the effects of a changing environment. By incorporating these effects, one could provide a framework for integrating 'omics' data from various levels of the system in order to provide interpretations with respect to the energy state and to elicit conclusions about putative global energy-related response mechanisms in the cell.

Results

Here we define a cost measure for amino acid synthesis based on flux balance analysis of a genome-scale metabolic network, and develop methods for its integration with proteomics and m

SUBMITTER: Sajitz-Hermstein M 

PROVIDER: S-EPMC2935400 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature