IAlign: a method for the structural comparison of protein-protein interfaces.

ABSTRACT:

Motivation

Protein-protein interactions play an essential role in many cellular processes. The rapid accumulation of protein-protein complex structures provides an unprecedented opportunity for comparative studies of protein-protein interactions. To facilitate such studies, it is necessary to develop an accurate and efficient computational algorithm for the comparison of protein-protein interaction modes. While there are many structural comparison approaches developed for individual proteins, very few methods are available for protein-protein complexes.

Results

We present a novel interface alignment method, iAlign, for the structural alignment of protein-protein interfaces. New scoring schemes for measuring interface similarity are introduced, and an iterative dynamic progra

SUBMITTER: Gao M 

PROVIDER: S-EPMC2935406 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature